If you’re not into kitchen experiments, hit the pharmacy. Grab a tube of hydrocortisone cream—the 1% stuff. It’s a mild steroid that tells your immune system to stop yelling.
Then, get an oral antihistamine like Benadryl or Zyrtec. The cream works on the spot, the pill works from the inside. It’s a double team against the itch. Think Batman and Robin, but for your skin.
One warning: Benadryl can make you sleepy. Do not take it before a job interview or operating heavy machinery. You want the spider bite to sleep, not you.