For the patient souls among us (or if you have a big loaf, like 3 pounds), try 325°F (160°C). This is the temperature for a tender, nearly melt-in-your-mouth texture. It takes longer – about 75 to 90 minutes – but the result is a loaf that slices like butter.
My neighbor Sarah swears by this method. She says it reminds her of her mother’s Sunday meatloaf, which always seemed to disappear before anyone remembered to pass the gravy. The lower heat gives the fat more time to render, keeping everything juicy and rich.
Just don’t peek every five minutes! Every time you open that oven door, you lose heat and extend the cooking time. Let the thermometer be your guide, not your impatience.
Cajun-Style Meatloaf Recipe